Preprodynorphin gene mutation causes progressive cardiac conduction disease: A whole-exome analysis of a pedigree.

Su, Jian-Yao; Zhang, Rong-Feng; Dong, Ying-Xue; Yang, Ming-Hui; Yin, Xiao-Meng; Gao, Lian-Jun; Li, Hui-Hua; Xia, Yun-Long; Yang, Yan-Zong

Su, Jian-Yao; Zhang, Rong-Feng; Dong, Ying-Xue; Yang, Ming-Hui; Yin, Xiao-Meng; Gao, Lian-Jun; Li, Hui-Hua; Xia, Yun-Long; Yang, Yan-Zong.

Su JY; Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Zhang RF; Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Dong YX; Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Yang MH; Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Yin XM; Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Gao LJ; Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Li HH; Department of Cardiology, Institute of Cardiovascular Disease, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Xia YL; Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. Electronic address: yunlong_xia@126.com.
Yang YZ; Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. Electronic address: yanzongyangdr@163.com.

Life Sci ; 219: 74-81, 2019 Feb 15.

Article en En | MEDLINE | ID: mdl-30611784

Asunto(s)

Trastorno del Sistema de Conducción Cardíaco/genética; Dinorfinas/genética; Exoma/genética; Mutación Missense/genética; Precursores de Proteínas/genética; Adulto; Trastorno del Sistema de Conducción Cardíaco/fisiopatología; Electrocardiografía; Femenino; Humanos; Masculino; Persona de Mediana Edad; Linaje; Reacción en Cadena de la Polimerasa; Análisis de Secuencia de ADN

Palabras clave

Familial; Gene mutation; PDYN; Progressive cardiac conduction disease; Whole-exome sequencing

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Precursores de Proteínas / Dinorfinas / Mutación Missense / Exoma / Trastorno del Sistema de Conducción Cardíaco Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article

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