Phage serine integrase-mediated genome engineering for efficient expression of chemical biosynthetic pathway in gas-fermenting Clostridium ljungdahlii.

Huang, He; Chai, Changsheng; Yang, Sheng; Jiang, Weihong; Gu, Yang

Huang, He; Chai, Changsheng; Yang, Sheng; Jiang, Weihong; Gu, Yang.

Huang H; Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Chai C; Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Yang S; Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China; Jiangsu National Synergetic Innovation Center for Advanced Materials, SICAM, 200 North Zhongshan Road,
Jiang W; Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China; Jiangsu National Synergetic Innovation Center for Advanced Materials, SICAM, 200 North Zhongshan Road,
Gu Y; Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China. Electronic address: ygu02@sibs.ac.cn.

Metab Eng ; 52: 293-302, 2019 03.

Article en En | MEDLINE | ID: mdl-30633974

Asunto(s)

Bacteriófagos/enzimología; Bacteriófagos/genética; Clostridium/genética; Clostridium/metabolismo; Integrasas/genética; Integrasas/metabolismo; Ingeniería Metabólica/métodos; Sitios de Ligazón Microbiológica/genética; Ácido Butírico/metabolismo; Sistemas CRISPR-Cas; ADN Bacteriano/genética; Fermentación; Genoma Bacteriano/genética; Redes y Vías Metabólicas/genética; Plásmidos/genética; Serina/metabolismo

Palabras clave

Att/Int system; Bacteriophage; Butyric acid production; Chromosomal integration; Gas-fermenting clostridia

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Bacteriófagos / Clostridium / Integrasas / Ingeniería Metabólica Idioma: En Año: 2019 Tipo del documento: Article

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