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Comparison of the Idylla™ Respiratory (IFV-RSV) panel with the GeneXpert Xpert® Flu/RSV assay: a retrospective study with nasopharyngeal and midturbinate samples.
Wouters, Yannick; Keyaerts, Els; Rector, Annabel; Van Even, Ellen; Vissers, Steven; Koletzki, Diana; Pattery, Theresa; Rousseau, Els; Van Ranst, Marc; Laffut, Wim.
  • Wouters Y; Department of Microbiology, Heilig Hart Hospital Lier, Mechelsestraat 24, 2500 Lier, Belgium.
  • Keyaerts E; Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Rector A; Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Van Even E; Department of Microbiology, Heilig Hart Hospital Lier, Mechelsestraat 24, 2500 Lier, Belgium.
  • Vissers S; Department of Anaesthesiology and Reanimation, Heilig Hart Hospital Lier, Mechelsestraat 24, 2500 Lier, Belgium.
  • Koletzki D; Janssen Diagnostics a division of Janssen Pharmaceutica NV, Antwerpseweg 15, 2340 Beerse, Belgium.
  • Pattery T; Janssen Diagnostics a division of Janssen Pharmaceutica NV, Antwerpseweg 15, 2340 Beerse, Belgium.
  • Rousseau E; Janssen Diagnostics a division of Janssen Pharmaceutica NV, Antwerpseweg 15, 2340 Beerse, Belgium.
  • Van Ranst M; Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Laffut W; Department of Microbiology, Heilig Hart Hospital Lier, Mechelsestraat 24, 2500 Lier, Belgium. Electronic address: wim.laffut@hhzhlier.be.
Diagn Microbiol Infect Dis ; 94(1): 33-37, 2019 May.
Article en En | MEDLINE | ID: mdl-30638655
ABSTRACT
The objective of this study was to compare the performance of the Idylla™ Respiratory (IFV-RSV) panel to the GeneXpert Xpert® Flu/RSV assay and establish the performance of a midturbinate swab compared to nasopharyngeal sampling. Considering GeneXpert® assay as imperfect reference standard, a positive percentage agreement between both assays of 98-100% for influenza A and 96-99% for influenza B could be calculated when 354 nasopharyngeal and 325 midturbinate swabs were retrospectively analyzed. Comparing midturbinate samples to nasopharyngeal specimens of 321 subjects, positive percentage agreement varied from 42% to 94% depending on both target virus and assay used. Negative percentage agreements ranged from 98% to 100% for both methods and sample type comparison. The Idylla™ assay showed excellent performance compared to the GeneXpert® assay for the detection of influenza virus. The study also showed a slightly better performance for nasopharyngeal sampling compared to the use of a midturbinate swab.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Orthomyxoviridae / Nasofaringe / Virus Sincitial Respiratorio Humano / Infecciones por Virus Sincitial Respiratorio / Técnicas de Diagnóstico Molecular / Gripe Humana / Cavidad Nasal Tipo de estudio: Diagnostic_studies / Evaluation_studies / Observational_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Año: 2019 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Orthomyxoviridae / Nasofaringe / Virus Sincitial Respiratorio Humano / Infecciones por Virus Sincitial Respiratorio / Técnicas de Diagnóstico Molecular / Gripe Humana / Cavidad Nasal Tipo de estudio: Diagnostic_studies / Evaluation_studies / Observational_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Año: 2019 Tipo del documento: Article