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Prognostic value of dynamic albumin-to-alkaline phosphatase ratio in limited stage small-cell lung cancer.
Li, Xiaogang; Li, Butuo; Zeng, Haiyan; Wang, Shijiang; Sun, Xindong; Yu, Yishan; Wang, Linlin; Yu, Jinming.
  • Li X; School of Medicine & Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, PR China.
  • Li B; Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Jinan, PR China.
  • Zeng H; Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Jinan, PR China.
  • Wang S; Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention & Therapy, Tianjin, PR China.
  • Sun X; Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Jinan, PR China.
  • Yu Y; Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Jinan, PR China.
  • Wang L; Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Jinan, PR China.
  • Yu J; Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Jinan, PR China.
Future Oncol ; 15(9): 995-1006, 2019 Mar.
Article en En | MEDLINE | ID: mdl-30644319
ABSTRACT

AIM:

To dynamically investigate the prognostic value of albumin-to-alkaline phosphatase ratio (AAPR) in limited stage small-cell lung cancer. MATERIALS &

METHODS:

 The AAPR within 1 week before and after chemoradiation therapy (pre- and post-AAPR) was collected and analyzed.

RESULTS:

Patients with low pre- or post-AAPR had shorter overall survival and progression-free survival than the high groups (p-values all <0.05). Post-AAPR was an independent prognostic factor for progression-free survival (p = 0.007) and overall survival (p = 0.003). The integration of pre- or post-AAPR improved the prognostic ability of Tumor, Node, Metastasis stage alone (0.55-0.64 and 0.68, respectively).

CONCLUSION:

 Post-AAPR is a reliable prognostic factor for limited stage small-cell lung cancer patients. The complementary value of AAPR to Tumor, Node, Metastasis stage is worth further validation in the future.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Fosfatasa Alcalina / Carcinoma Pulmonar de Células Pequeñas / Albúmina Sérica Humana / Neoplasias Pulmonares Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Fosfatasa Alcalina / Carcinoma Pulmonar de Células Pequeñas / Albúmina Sérica Humana / Neoplasias Pulmonares Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article