Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age.
Neuron
; 101(3): 459-471.e5, 2019 02 06.
Article
en En
| MEDLINE
| ID: mdl-30654924
ABSTRACT
Oligodendrocyte progenitor cells (OPCs), which differentiate into myelinating oligodendrocytes during CNS development, are the main proliferative cells in the adult brain. OPCs are conventionally considered a homogeneous population, particularly with respect to their electrophysiological properties, but this has been debated. We show, by using single-cell electrophysiological recordings, that OPCs start out as a homogeneous population but become functionally heterogeneous, varying both within and between brain regions and with age. These electrophysiological changes in OPCs correlate with the differentiation potential of OPCs; thus, they may underlie the differentiational differences in OPCs between regions and, likewise, differentiation failure with age.
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Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
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Oligodendroglía
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Células-Madre Neurales
Límite:
Animals
Idioma:
En
Año:
2019
Tipo del documento:
Article