Some remarks on application of macrophages in tumor therapy.

This short review concerns some select aspects of macrophage-activating therapy against tumor. It has been agreed that one of the major host antitumor defense components is the mononuclear phagocyte system. The possibilities of macrophage application in tumor treatment comprise the adoptive transfer of tumoricidal macrophages, the regional administration of macrophage activators, and the systemic administration of such activators given in free form and/or entrapped in liposomes. Special attention is turned to the activation of macrophages by liposome-encapsulated activators.