Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis.

Miyata, Jun; Fukunaga, Koichi; Kawashima, Yusuke; Watanabe, Takashi; Saitoh, Akina; Hirosaki, Tomomi; Araki, Yasutomo; Kikawada, Toru; Betsuyaku, Tomoko; Ohara, Osamu; Arita, Makoto

Miyata, Jun; Fukunaga, Koichi; Kawashima, Yusuke; Watanabe, Takashi; Saitoh, Akina; Hirosaki, Tomomi; Araki, Yasutomo; Kikawada, Toru; Betsuyaku, Tomoko; Ohara, Osamu; Arita, Makoto.

Miyata J; Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Fukunaga K; Graduate School of Medical Life Science, Yokohama City University, Kanagawa, Japan.
Kawashima Y; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Watanabe T; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Saitoh A; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Hirosaki T; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Araki Y; Tsukuba Research Institute, Ono Pharmaceutical Co., Ltd., Tsukuba, Japan.
Kikawada T; Minase Research Institute, Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Betsuyaku T; Nose Clinic Tokyo, Tokyo, Japan.
Ohara O; Nose Clinic Tokyo, Tokyo, Japan.
Arita M; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

Allergy ; 74(6): 1113-1124, 2019 06.

Article en En | MEDLINE | ID: mdl-30667533

Asunto(s)

Eosinófilos/metabolismo; Ácidos Grasos/metabolismo; Pólipos Nasales/patología; Rinitis/metabolismo; Sinusitis/metabolismo; Adulto; Araquidonato 15-Lipooxigenasa/metabolismo; Donantes de Sangre; Células Cultivadas; Enfermedad Crónica; Citocinas/farmacología; Eosinófilos/efectos de los fármacos; Femenino; Humanos; Leucotrieno D4/metabolismo; Masculino; Persona de Mediana Edad; Pólipos Nasales/inmunología; Fenotipo; Prostaglandina-Endoperóxido Sintasas/metabolismo; Proteoma; Rinitis/patología; Transducción de Señal/efectos de los fármacos; Sinusitis/patología; Transcriptoma; gamma-Glutamiltransferasa/metabolismo

Palabras clave

GGT5; chronic rhinosinusitis; human eosinophil; lipid mediator; multi-omics

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sinusitis / Rinitis / Pólipos Nasales / Eosinófilos / Ácidos Grasos Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article

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