Hospital-based screening to detect patients with cadmium nephropathy in cadmium-polluted areas in Japan.
Environ Health Prev Med
; 24(1): 8, 2019 Jan 26.
Article
en En
| MEDLINE
| ID: mdl-30684957
ABSTRACT
BACKGROUND:
In health examinations for local inhabitants in cadmium-polluted areas, only healthy people are investigated, suggesting that patients with severe cadmium nephropathy or itai-itai disease may be overlooked. Therefore, we performed hospital-based screening to detect patients with cadmium nephropathy in two core medical institutes in cadmium-polluted areas in Akita prefecture, Japan.METHODS:
Subjects for this screening were selected from patients aged 60 years or older with elevated serum creatinine levels and no definite renal diseases. We enrolled 35 subjects from a hospital in Odate city and 22 from a clinic in Kosaka town. Urinary ß2-microglobulin and blood and urinary cadmium levels were measured.RESULTS:
The criteria for renal tubular dysfunction and the over-accumulation of cadmium were set as a urinary ß2-microglobulin level higher than 10,000 µg/g cr. and a blood cadmium level higher than 6 µg/L or urinary cadmium level higher than 10 µg/g cr., respectively. Subjects who fulfilled both criteria were diagnosed with cadmium nephropathy. Six out of 57 patients (10.5% of all subjects) had cadmium nephropathy.CONCLUSIONS:
This hospital-based screening is a very effective strategy for detecting patients with cadmium nephropathy in cadmium-polluted areas, playing a complementary role in health examinations for local inhabitants. REGISTRATION NUMBER No. 6, date of registration 6 June, 2010 (Akita Rosai Hospital), and No. 1117, date of registration 26 December, 2013 (Akita University).Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cadmio
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Intoxicación por Cadmio
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Contaminantes Ambientales
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Enfermedades Renales
Tipo de estudio:
Diagnostic_studies
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Screening_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País como asunto:
Asia
Idioma:
En
Año:
2019
Tipo del documento:
Article