[Incidence of depressive disorders and related independent risk factors in patients with chronic hepatitis C].
Zhonghua Gan Zang Bing Za Zhi
; 27(1): 33-38, 2019 Jan 20.
Article
en Zh
| MEDLINE
| ID: mdl-30685921
ABSTRACT
Objective:
To investigate the incidence and related independent risk factors of depression in treatment-naïve Han ethnic Chinese patients with chronic hepatitis C.Methods:
Nine hundred and ninety-seven Han Chinese patients with confirmed chronic HCV infection were enrolled. Beck's depression inventory scale was used to assess depression score. Patients were divided into two groups according to the score score≥17, depression group (16.85%, 168/997); score <17, no depression group (83.15%, 829/997). Multivariate logistic regression was used to analyze independent risk factors related with the onset of depression in patients with chronic hepatitis C.Results:
There was a statistically significant difference between the two groups in terms of gender distribution, marital status, education level, income level and smoking status (P < 0.05). Independent risk factors were female [odds ratio (OR) = 3.85; 95% CI 2.28-6.50, P = 0.001], decompensated cirrhosis [OR = 2.31; 95% CI 1.20-4.48, P = 0.013], unmarried [OR = 2.01; 95% CI 1.12-3.60, P = 0.019], separated [OR = 17.39; 95% CI 1.64-184.47, P = 0.018], divorced [OR = 3.82; 95% CI 1.36-10.74, P = 0.011], without higher education [OR = 2.04; 95% CI 1.22-3.42, P = 0.007], low income [OR = 3.94; 95% CI 1.38-11.28, P = 0.011], middle income [OR = 2.96; 95% CI 1.02-8.62, P = 0.047], uninterrupted smoking [OR = 3.67; 95% CI 2.13-6.31, P = 0.001], and previously smoked [OR = 3.33, 95% CI 1.66-6.68, P = 0.001].Conclusion:
The incidence of depression in patients with chronic hepatitis C is relatively high. The independent risk factors related with depression include female, unmarried, separated, and divorced, without higher education, low and middle-income level, smoking and disease progression to decompensated cirrhosis, but no significant correlation between hepatitis C virus genotypes and viral load.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Hepatitis C
/
Hepatitis C Crónica
/
Trastorno Depresivo
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
País como asunto:
Asia
Idioma:
Zh
Año:
2019
Tipo del documento:
Article