[Genetic polymorphisms of 23 autosomal short tandem repeat loci among ethnic Han Chinese from southern China].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 36(2): 171-174, 2019 Feb 10.
Article
en Zh
| MEDLINE
| ID: mdl-30703241
ABSTRACT
OBJECTIVE:
To study genetic polymorphisms of 23 autosomal short tandem repeat (STR) loci among ethnic Han Chinese from southern China.METHODS:
The 23 autosomal STR loci among 331 unrelated healthy Han Chinese from southern China were genotyped with fluorescent multiplex amplification and capillary electrophoresis. Genetic parameters were subjected to statistical analysis.RESULTS:
In total 265 alleles and 890 genotypes were detected for the 23 STR loci. The numbers of alleles were 5-22, allelic frequency was 0.0015-0.5483, heterozygosity was 0.5891-0.9124, power of discrimination was 0.7818-0.9831, polymorphic information content was 0.5425-0.9031, probability of exclusion for trio-paternity testing was 0.2780-0.8208, and probability of exclusion for duo-paternity testing was 0.193-0.693. The combined power of discrimination was over 0.999 999 999 999 99, the combined probability of exclusion for trio-paternity identification was 0.999 999 999 729 813, and the combined probability of exclusion for duo-paternity identification was 0.999 999 207 508 474, respectively. The 23 STR loci showed no significant deviation from Hardy-Weinberg disequilibrium after Bonferroni correction (P> 0.05).CONCLUSION:
The 23 autosomal STR loci were highly polymorphic among ethnic Han Chinese from southern China, which showed a high efficiency for paternity testing, personal identification and population genetics.
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Banco de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Repeticiones de Microsatélite
Límite:
Humans
País como asunto:
Asia
Idioma:
Zh
Año:
2019
Tipo del documento:
Article