IgG4:IgG RNA ratio differentiates active disease from remission in granulomatosis with polyangiitis: a new disease activity marker? A cross-sectional and longitudinal study.

Al-Soudi, A; Doorenspleet, M E; Esveldt, R E; Burgemeister, L T; Hak, A E; van den Born, B J H; Tas, S W; van Vollenhoven, R F; Klarenbeek, P L; de Vries, N

Al-Soudi, A; Doorenspleet, M E; Esveldt, R E; Burgemeister, L T; Hak, A E; van den Born, B J H; Tas, S W; van Vollenhoven, R F; Klarenbeek, P L; de Vries, N.

Al-Soudi A; Department of Rheumatology & Clinical Immunology and Amsterdam Rheumatology and Immunology Center (ARC), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. a.alsoudi@amc.uva.nl.
Doorenspleet ME; Department of Genome Analysis, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. a.alsoudi@amc.uva.nl.
Esveldt RE; Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. a.alsoudi@amc.uva.nl.
Burgemeister LT; Department of Rheumatology & Clinical Immunology and Amsterdam Rheumatology and Immunology Center (ARC), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Hak AE; Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
van den Born BJH; Department of Rheumatology & Clinical Immunology and Amsterdam Rheumatology and Immunology Center (ARC), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Tas SW; Department of Genome Analysis, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
van Vollenhoven RF; Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Klarenbeek PL; Department of Rheumatology & Clinical Immunology and Amsterdam Rheumatology and Immunology Center (ARC), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
de Vries N; Department of Rheumatology & Clinical Immunology and Amsterdam Rheumatology and Immunology Center (ARC), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Arthritis Res Ther ; 21(1): 43, 2019 01 31.

Article en En | MEDLINE | ID: mdl-30704507

Asunto(s)

Anticuerpos Anticitoplasma de Neutrófilos/inmunología; Linfocitos B/inmunología; Granulomatosis con Poliangitis/diagnóstico; Inmunoglobulina G/genética; Mieloblastina/inmunología; Células Plasmáticas/inmunología; ARN/genética; Adulto; Anciano; Anticuerpos Anticitoplasma de Neutrófilos/sangre; Linfocitos B/metabolismo; Biomarcadores/sangre; Estudios Transversales; Diagnóstico Diferencial; Femenino; Granulomatosis con Poliangitis/genética; Granulomatosis con Poliangitis/inmunología; Humanos; Inmunoglobulina G/sangre; Inmunoglobulina G/inmunología; Estudios Longitudinales; Masculino; Persona de Mediana Edad; Mieloblastina/metabolismo; Células Plasmáticas/metabolismo; ARN/sangre; ARN/inmunología; Remisión Espontánea; Adulto Joven

Palabras clave

Biomarkers; Disease activity; Granulomatosis with polyangiitis; Immunoglobulin G4; Quantitative polymerase chain reaction

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células Plasmáticas / Inmunoglobulina G / ARN / Linfocitos B / Granulomatosis con Poliangitis / Anticuerpos Anticitoplasma de Neutrófilos / Mieloblastina Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article

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