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DPYD*6 plays an important role in fluoropyrimidine toxicity in addition to DPYD*2A and c.2846A>T: a comprehensive analysis in 1254 patients.
Del Re, Marzia; Cinieri, Saverio; Michelucci, Angela; Salvadori, Stefano; Loupakis, Fotios; Schirripa, Marta; Cremolini, Chiara; Crucitta, Stefania; Barbara, Cecilia; Di Leo, Angelo; Latiano, Tiziana Pia; Pietrantonio, Filippo; Di Donato, Samantha; Simi, Paolo; Passardi, Alessandro; De Braud, Filippo; Altavilla, Giuseppe; Zamagni, Claudio; Bordonaro, Roberto; Butera, Alfredo; Maiello, Evaristo; Pinto, Carmine; Falcone, Alfredo; Mazzotti, Valentina; Morganti, Riccardo; Danesi, Romano.
  • Del Re M; Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Cinieri S; Medical Oncology Division and Breast Unit, Civil Hospital, Brindisi, Italy.
  • Michelucci A; Medical Genetics Unit, Department of Laboratory Medicine, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
  • Salvadori S; Epidemiology and Health Services Research Department, Institute of Clinical Physiology, National Research Council (CNR), Pisa, Italy.
  • Loupakis F; Medical Oncology Unit, Istituto Oncologico del Veneto IRCCS, Padova, Italy.
  • Schirripa M; Medical Oncology Unit, Istituto Oncologico del Veneto IRCCS, Padova, Italy.
  • Cremolini C; Medical Oncology Unit, Department of Translational Research and New Technologies in Medicine, University of Pisa, Pisa, Italy.
  • Crucitta S; Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Barbara C; Medical Oncology Unit, Civil Hospital, Livorno, Italy.
  • Di Leo A; Medical Oncology Unit, Civil Hospital, Prato, Italy.
  • Latiano TP; Medical Oncology Unit, Casa Sollievo della Sofferenza IRCCS, San Giovanni Rotondo, Italy.
  • Pietrantonio F; Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
  • Di Donato S; Medical Oncology Unit, Civil Hospital, Prato, Italy.
  • Simi P; Medical Genetics Unit, Department of Laboratory Medicine, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
  • Passardi A; Medical Oncology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRCCS, Meldola, Italy.
  • De Braud F; Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
  • Altavilla G; Medical Oncology Unit, Department of Human Pathology, University of Messina, Messina, Italy.
  • Zamagni C; Medical Oncology Unit, Addarii Institute of Oncology, S. Orsola-Malpighi Hospital, Bologna, Italy.
  • Bordonaro R; Medical Oncology Unit, Department of Oncology, ARNAS Garibaldi, Catania, Italy.
  • Butera A; Medical Oncology Unit, Department of Oncology, Civil Hospital, Agrigento, Italy.
  • Maiello E; Medical Oncology Unit, Casa Sollievo della Sofferenza IRCCS, San Giovanni Rotondo, Italy.
  • Pinto C; Medical Oncology Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy.
  • Falcone A; Medical Oncology Unit, Department of Translational Research and New Technologies in Medicine, University of Pisa, Pisa, Italy.
  • Mazzotti V; Statistics Applied to Clinical Trials Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
  • Morganti R; Statistics Applied to Clinical Trials Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
  • Danesi R; Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. romano.danesi@unipi.it.
Pharmacogenomics J ; 19(6): 556-563, 2019 12.
Article en En | MEDLINE | ID: mdl-30723313
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirimidinas / Polimorfismo de Nucleótido Simple / Dihidrouracilo Deshidrogenasa (NADP) / Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirimidinas / Polimorfismo de Nucleótido Simple / Dihidrouracilo Deshidrogenasa (NADP) / Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article