Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism.
Curr Biol
; 29(4): 592-604.e4, 2019 02 18.
Article
en En
| MEDLINE
| ID: mdl-30744968
ABSTRACT
Successful reproduction in female mammals is precisely timed and must be able to withstand the metabolic demand of pregnancy and lactation. We show that kisspeptin-expressing neurons in the arcuate hypothalamus (Kiss1ARH) of female mice control the daily timing of food intake, along with the circadian regulation of locomotor activity, sleep, and core body temperature. Toxin-induced silencing of Kiss1ARH neurons shifts wakefulness and food consumption to the light phase and induces weight gain. Toxin-silenced mice are less physically active and have attenuated temperature rhythms. Because the rhythm of the master clock in the suprachiasmatic nucleus (SCN) appears to be intact, we hypothesize that Kiss1ARH neurons signal to neurons downstream of the master clock to modulate the output of the SCN. We conclude that, in addition to their well-established role in regulating fertility, Kiss1ARH neurons are a critical component of the hypothalamic circadian oscillator network that times overt rhythms of physiology and behavior.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Núcleo Arqueado del Hipotálamo
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Ritmo Circadiano
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Kisspeptinas
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Neuronas
Límite:
Animals
Idioma:
En
Año:
2019
Tipo del documento:
Article