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3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel.
Sutherland, Hamish S; Tong, Amy S T; Choi, Peter J; Blaser, Adrian; Conole, Daniel; Franzblau, Scott G; Lotlikar, Manisha U; Cooper, Christopher B; Upton, Anna M; Denny, William A; Palmer, Brian D.
  • Sutherland HS; Auckland Cancer Society Research Centre, School of Medical Sciences, New Zealand.
  • Tong AST; Auckland Cancer Society Research Centre, School of Medical Sciences, New Zealand.
  • Choi PJ; Auckland Cancer Society Research Centre, School of Medical Sciences, New Zealand.
  • Blaser A; Auckland Cancer Society Research Centre, School of Medical Sciences, New Zealand.
  • Conole D; Auckland Cancer Society Research Centre, School of Medical Sciences, New Zealand; Maurice Wilkins Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago
  • Franzblau SG; Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA.
  • Lotlikar MU; Global Alliance for TB Drug Development, 40 Wall St, NY 10005, USA.
  • Cooper CB; Global Alliance for TB Drug Development, 40 Wall St, NY 10005, USA.
  • Upton AM; Global Alliance for TB Drug Development, 40 Wall St, NY 10005, USA.
  • Denny WA; Auckland Cancer Society Research Centre, School of Medical Sciences, New Zealand; Maurice Wilkins Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address: b.denny@auckland.ac.nz.
  • Palmer BD; Auckland Cancer Society Research Centre, School of Medical Sciences, New Zealand; Maurice Wilkins Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Bioorg Med Chem ; 27(7): 1292-1307, 2019 04 01.
Article en En | MEDLINE | ID: mdl-30803745
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Bloqueadores de los Canales de Potasio / Canales de Potasio Éter-A-Go-Go / Diarilquinolinas / Mycobacterium tuberculosis / Antituberculosos Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Bloqueadores de los Canales de Potasio / Canales de Potasio Éter-A-Go-Go / Diarilquinolinas / Mycobacterium tuberculosis / Antituberculosos Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article