Maternal-biased H3K27me3 correlates with paternal-specific gene expression in the human morula.
Genes Dev
; 33(7-8): 382-387, 2019 04 01.
Article
en En
| MEDLINE
| ID: mdl-30808660
ABSTRACT
Genomic imprinting is an epigenetic mechanism by which genes are expressed in a parental origin-dependent manner. We recently discovered that, like DNA methylation, oocyte-inherited H3K27me3 can also serve as an imprinting mark in mouse preimplantation embryos. In this study, we found H3K27me3 is strongly biased toward the maternal allele with some associated with DNA methylation-independent paternally expressed genes (PEGs) in human morulae. The H3K27me3 domains largely overlap with DNA partially methylated domains (PMDs) and occupy developmental gene promoters. Thus, our study not only reveals the H3K27me3 landscape but also establishes a correlation between maternal-biased H3K27me3 and PEGs in human morulae.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Histonas
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Impresión Genómica
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Regulación del Desarrollo de la Expresión Génica
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Mórula
Límite:
Female
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Humans
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Male
Idioma:
En
Año:
2019
Tipo del documento:
Article