Polyunsaturated fatty acids and child neurodevelopment among a population exposed to DDT: a cohort study.
Environ Health
; 18(1): 17, 2019 02 28.
Article
en En
| MEDLINE
| ID: mdl-30819201
ABSTRACT
BACKGROUND:
Child neurodevelopment has been positively linked to maternal intake of polyunsaturated fatty acids (PUFAs) during pregnancy; however, it is unknown if that relationship persists among populations exposed to environmental neurotoxicants.OBJECTIVE:
The aim of this work was to assess whether maternal dietary intake of PUFAs during pregnancy is positively associated with child neurodevelopment, whose mothers were environmentally exposed to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT).METHODS:
A prospective cohort study with 276 mother-child pairs was performed in Mexico. Neurodevelopment was assessed by Bayley Scales II from children age 1 to 30 months. Dietary PUFAs intake was estimated by Food Frequency Questionnaire at 1st and 3rd trimester of pregnancy. DDE (1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene, the main metabolite of DDT) maternal serum levels were determined by electron capture gas chromatography. Longitudinal multivariate linear mixed-effects analysis, which combines mental (MDI) and motor (PDI) Bayley scales in a single model, were performed.RESULTS:
Our results show that in a sample environmentally exposed to DDT, maternal ingestion of DPA during the first trimester of pregnancy was positively associated with MDI (ß = 0.10, 95% CI 0.02, 0.18) in children from 1 to 30 months. Likewise, our results suggest that dietary ALA may be also related to MDI.CONCLUSION:
DPA may benefit neurodevelopment even in populations exposed to DDT. Our results strengthen the importance of PUFAs intake during the prenatal period.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Desarrollo Infantil
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Exposición Materna
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DDT
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Contaminantes Ambientales
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Ácidos Grasos Insaturados
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Insecticidas
Tipo de estudio:
Etiology_studies
/
Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Child, preschool
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Female
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Humans
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Infant
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Newborn
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Pregnancy
País como asunto:
Mexico
Idioma:
En
Año:
2019
Tipo del documento:
Article