Synthesis and antitumor activity evaluation of ursolic acid derivatives.
J Asian Nat Prod Res
; 22(4): 359-369, 2020 Apr.
Article
en En
| MEDLINE
| ID: mdl-30829054
ABSTRACT
Eighteen uronic acid derivatives were designed and synthesized, and the cytotoxicities in vitro of two cancer cell lines (BEL7402 and SGC7901) were evaluated by MTT assay. The results showed that the inhibitory rate of the compounds on both cell lines was significantly higher than the parent compound. The IC50 of compounds II4, II6, III4, and III6 are comparable or stronger than the positive control drug, the interactions between compounds II4, II6, III4, III6, and NF-κB were also studied by docking simulations.
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Banco de datos:
MEDLINE
Asunto principal:
Antineoplásicos
Idioma:
En
Año:
2020
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Article