α-Glucosidase Inhibitory Flavonoids and Oxepinones from the Leaf and Twig Extracts of Desmos cochinchinensis.
J Nat Prod
; 82(4): 741-747, 2019 04 26.
Article
en En
| MEDLINE
| ID: mdl-30835120
ABSTRACT
Four new flavonoids (1-4), a new benzyl benzoate derivative (5), five new oxepinones (6-10), and 14 known compounds (11-24) were isolated from the leaf and twig extracts of Desmos cochinchinensis. Their structures were established by spectroscopic methods. The structure of 1 was also confirmed by X-ray diffraction data. The absolute configurations of 3, 4, and 6-10 were determined from comparisons of their ECD spectra with those of relevant reported compounds. Compounds 1, 2, 6, 8, 10, 12-15, and 17 showed α-glucosidase inhibitory activities with IC50 values ranging from 0.2 to 4.9 µM.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Oxepinas
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Flavonoides
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Extractos Vegetales
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Hojas de la Planta
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Annonaceae
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Alfa-Glucosidasas
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Inhibidores de Glicósido Hidrolasas
Idioma:
En
Año:
2019
Tipo del documento:
Article