Stem cell therapies for acute spinal cord injury in humans: a review.
Neurosurg Focus
; 46(3): E10, 2019 03 01.
Article
en En
| MEDLINE
| ID: mdl-30835679
ABSTRACT
Recent advances in stem cell biology present significant opportunities to advance clinical applications of stem cell-based therapies for spinal cord injury (SCI). In this review, the authors critically analyze the basic science and translational evidence that supports the use of various stem cell sources, including induced pluripotent stem cells, oligodendrocyte precursor cells, and mesenchymal stem cells. They subsequently explore recent advances in stem cell biology and discuss ongoing clinical translation efforts, including combinatorial strategies utilizing scaffolds, biogels, and growth factors to augment stem cell survival, function, and engraftment. Finally, the authors discuss the evolution of stem cell therapies for SCI by providing an overview of completed (n = 18) and ongoing (n = 9) clinical trials.
Palabras clave
AD-MSC = adipose-derived MSC; ASIA = American Spinal Injury Association; BDNF = brain-derived neurotrophic factor; BM-MSC = bone marrowderived MSC; BMP = bone morphogenetic protein; ESC = embryonic stem cell; MEP = motor evoked potential; MSC = mesenchymal stem cell; NPC = neural progenitor cell; OPC = oligodendrocyte progenitor cell; SCI = spinal cord injury; TGFß = transforming growth factorß; U-MSC = umbilical cord MSC; clinical trials; iPSC = induced pluripotent stem cell; spinal cord injury; stem cell; transplant; trauma
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Traumatismos de la Médula Espinal
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Trasplante de Células Madre Mesenquimatosas
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Células Madre Pluripotentes Inducidas
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Células Precursoras de Oligodendrocitos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article