Whole-exome sequencing revealed mutational profiles of giant cell glioblastomas.

Shi, Zhi-Feng; Li, Kay Ka-Wai; Kwan, Johnny Sheung Him; Yang, Rui Ryan; Aibaidula, Abudumijiti; Tang, Qisheng; Bao, Yifeng; Mao, Ying; Chen, Hong; Ng, Ho-Keung

Shi, Zhi-Feng; Li, Kay Ka-Wai; Kwan, Johnny Sheung Him; Yang, Rui Ryan; Aibaidula, Abudumijiti; Tang, Qisheng; Bao, Yifeng; Mao, Ying; Chen, Hong; Ng, Ho-Keung.

Shi ZF; Department of Neurosurgery, Huashan Hospital, Fudan University, Wulumuqi Zhong Road 12, Shanghai, 200040, China.
Li KK; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong, China.
Kwan JSH; Shenzhen Research Institute, The Chinese University of Hong Kong, No.10, 2nd Yuexing Road, Nanshan District, Shenzhen, 518057, China.
Yang RR; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong, China.
Aibaidula A; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong, China.
Tang Q; Department of Neurosurgery, Huashan Hospital, Fudan University, Wulumuqi Zhong Road 12, Shanghai, 200040, China.
Bao Y; Department of Neurosurgery, Huashan Hospital, Fudan University, Wulumuqi Zhong Road 12, Shanghai, 200040, China.
Mao Y; Department of Neurosurgery, Huashan Hospital, Fudan University, Wulumuqi Zhong Road 12, Shanghai, 200040, China.
Chen H; Department of Neurosurgery, Huashan Hospital, Fudan University, Wulumuqi Zhong Road 12, Shanghai, 200040, China.
Ng HK; Department of Pathology, Huashan Hospital, Fudan University, Wulumuqi Zhong Road 12, Shanghai, 200040, China.

Brain Pathol ; 29(6): 782-792, 2019 11.

Article en En | MEDLINE | ID: mdl-30861589

Asunto(s)

Glioblastoma/genética; Adolescente; Adulto; Anciano; Neoplasias Encefálicas/genética; Fosfatidilinositol 3-Quinasa Clase Ia/genética; Estudios de Cohortes; Variaciones en el Número de Copia de ADN/genética; Metilasas de Modificación del ADN/genética; Enzimas Reparadoras del ADN/genética; Femenino; Glioblastoma/metabolismo; N-Metiltransferasa de Histona-Lisina/genética; Humanos; Masculino; Persona de Mediana Edad; Mutación; Pronóstico; Proteínas de Unión a Retinoblastoma/genética; Telomerasa/genética; Proteínas Supresoras de Tumor/genética; Ubiquitina-Proteína Ligasas/genética; Secuenciación del Exoma/métodos; Proteína Nuclear Ligada al Cromosoma X/genética

Palabras clave

giant cell glioblastoma; hypermutation phenotype; whole-exome sequencing

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glioblastoma Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article

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