3D printing in experimental orthopaedic surgery: do it yourself.
Eur J Orthop Surg Traumatol
; 29(5): 967-973, 2019 Jul.
Article
en En
| MEDLINE
| ID: mdl-30864016
ABSTRACT
INTRODUCTION:
Periprosthetic infection is considered an increasing incidence pathology whose therapeutic strategies can be defined as unsatisfactory. Currently, animal models are employed to study its physiopathology and strategic therapies, but non-species-specific materials are implanted as foreign bodies. The use of these implants implies intrinsic instability, which hinders the development of a biofilm on their surfaces and complicates the post-operative recovery of the animal. The objective of the present study is the design of a species-specific implant for the New Zealand white (NZW) rabbit by means of 3D printing. MATERIALS ANDMETHODS:
A CT scan of the knee of a NZW rabbit was performed, and the tibial surface was reconstructed in order to fabricate a species-specific tibial plateau using Horos® and Autodesk® Meshmixer™ software. This implant was inserted in fifteen NZW rabbits, and the assessment of its stability was based on the position of the limb at rest and the animal weight-bearing capacity. Biofilm formation on the surface was demonstrated by crystal violet staining.RESULTS:
A 1.81 cm × 1 cm × 1.24 cm stainless steel implant was designed. It consisted of a 4-mm-thick tibial plate with a rough surface and an eccentric metaphyseal anchoring. All of the animals exhibited hyperflexion of the operated limb immediately post-operative, and 100% could apply full weight bearing from day 5 after surgery.CONCLUSIONS:
The species-specific design of implants in experimental surgery encourages rapid recovery of the animal and the development of a biofilm on their surfaces, making them ideal for the study of the physiopathology and for establishing possible therapeutic targets for prosthetic infection.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Diseño de Prótesis
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Placas Óseas
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Diseño Asistido por Computadora
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Artroplastia de Reemplazo de Rodilla
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Modelos Animales
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Articulación de la Rodilla
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Prótesis de la Rodilla
Límite:
Animals
Idioma:
En
Año:
2019
Tipo del documento:
Article