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Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry.
Zhang, Hao; Gutruf, Philipp; Meacham, Kathleen; Montana, Michael C; Zhao, Xingyue; Chiarelli, Antonio M; Vázquez-Guardado, Abraham; Norris, Aaron; Lu, Luyao; Guo, Qinglei; Xu, Chenkai; Wu, Yixin; Zhao, Hangbo; Ning, Xin; Bai, Wubin; Kandela, Irawati; Haney, Chad R; Chanda, Debashis; Gereau, Robert W; Rogers, John A.
  • Zhang H; Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Gutruf P; Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Meacham K; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
  • Montana MC; Department of Biomedical Engineering, University of Arizona, Tucson, AZ 85721, USA.
  • Zhao X; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Chiarelli AM; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Vázquez-Guardado A; Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  • Norris A; State Key Laboratory of New Ceramics and Fine Processing and School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
  • Lu L; Institute of Advanced Biomedical Technologies and Department of Neuroscience, Imaging and Clinical Sciences, University G. D'Annunzio of Chieti-Pescara, Chieti 66100, Italy.
  • Guo Q; NanoScience Technology Center, Department of Physics and CREOL, The College of Optics and Photonics, University of Central Florida, Orlando, FL 32826, USA.
  • Xu C; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Wu Y; Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  • Zhao H; Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  • Ning X; Department of Materials Science, Fudan University, Shanghai 200433, China.
  • Bai W; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Kandela I; Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Haney CR; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
  • Chanda D; Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  • Gereau RW; Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Rogers JA; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
Sci Adv ; 5(3): eaaw0873, 2019 03.
Article en En | MEDLINE | ID: mdl-30873435
ABSTRACT
Monitoring regional tissue oxygenation in animal models and potentially in human subjects can yield insights into the underlying mechanisms of local O2-mediated physiological processes and provide diagnostic and therapeutic guidance for relevant disease states. Existing technologies for tissue oxygenation assessments involve some combination of disadvantages in requirements for physical tethers, anesthetics, and special apparatus, often with confounding effects on the natural behaviors of test subjects. This work introduces an entirely wireless and fully implantable platform incorporating (i) microscale optoelectronics for continuous sensing of local hemoglobin dynamics and (ii) advanced designs in continuous, wireless power delivery and data output for tether-free operation. These features support in vivo, highly localized tissue oximetry at sites of interest, including deep brain regions of mice, on untethered, awake animal models. The results create many opportunities for studying various O2-mediated processes in naturally behaving subjects, with implications in biomedical research and clinical practice.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Suministros de Energía Eléctrica / Prótesis e Implantes / Oximetría / Tecnología Inalámbrica Tipo de estudio: Guideline Límite: Animals Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Suministros de Energía Eléctrica / Prótesis e Implantes / Oximetría / Tecnología Inalámbrica Tipo de estudio: Guideline Límite: Animals Idioma: En Año: 2019 Tipo del documento: Article