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Activity and safety of metronomic cyclophosphamide in the modern era of metastatic castration-resistant prostate cancer.
Caffo, Orazio; Facchini, Gaetano; Biasco, Elisa; Ferraù, Francesco; Morelli, Franco; Donini, Maddalena; Buttigliero, Consuelo; Calvani, Nicola; Guida, Annalisa; Chiuri, Vincenzo Emanuele; Basso, Umberto; Mucciarini, Claudia; Conteduca, Vincenza; Rossetti, Sabrina; Veccia, Antonello; Maines, Francesca; Kinspergher, Stefania; De Giorgi, Ugo.
  • Caffo O; Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 38122 Trento, Italy.
  • Facchini G; Departmental Unit of Clinical & Experimental Uro-Andrologic Oncology, Istituto Nazionale Tumori, IRCCS, Fondazione G Pascale, Via Mariano Semmola 52, 80131 Naples, Italy.
  • Biasco E; Oncology Unit 2, University Hospital, Via Paradisa 2, 56124 Pisa, Italy.
  • Ferraù F; Medical Oncology Department, San Vincenzo Hospital, Via Sirina, 98039 Taormina, Italy.
  • Morelli F; Medical Oncology Department, Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Italy.
  • Donini M; Medical Oncology Department, General Hospital, Viale Concordia, 26100 Cremona, Italy.
  • Buttigliero C; Medical Oncology Department, University of Torino, San Luigi Hospital, Regione Gonzole 10, 10043 Orbassano, Italy.
  • Calvani N; Medical Oncology Division & Breast Unit, Antonio Perrino Hospital, 72100 Brindisi, Italy.
  • Guida A; Medical Oncology Division, Azienda Ospedaliero Universitaria, Policlinico di Modena, 41100 Modena, Italy.
  • Chiuri VE; Medical Oncology Unit, Vito Fazzi Hospital, 73100 Lecce, Italy.
  • Basso U; Medical Oncology Unit 1, Istituto Oncologico Veneto IOV, IRCCS, 35128 Padua, Italy.
  • Mucciarini C; Medical Oncology Department, General Hospital, 41012 Carpi, Italy.
  • Conteduca V; Medical Oncology Department, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola, Italy.
  • Rossetti S; Departmental Unit of Clinical & Experimental Uro-Andrologic Oncology, Istituto Nazionale Tumori, IRCCS, Fondazione G Pascale, Via Mariano Semmola 52, 80131 Naples, Italy.
  • Veccia A; Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 38122 Trento, Italy.
  • Maines F; Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 38122 Trento, Italy.
  • Kinspergher S; Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 38122 Trento, Italy.
  • De Giorgi U; Medical Oncology Department, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola, Italy.
Future Oncol ; 15(10): 1115-1123, 2019 04.
Article en En | MEDLINE | ID: mdl-30887825
ABSTRACT

AIM:

To evaluate activity of metronomic cyclophosphamide (mCTX) in heavily pretreated metastatic castration-resistant prostate cancer (mCRPC) patients. PATIENTS &

METHODS:

We retrospectively evaluated a consecutive series of 74 mCRPC patients treated with at least one new agent after docetaxel failure, who received once-daily oral mCTX treatment at a fixed dose of 50 mg.

RESULTS:

The treatment was well tolerated. Sixteen percent of the patients experienced a major biochemical response. Median progression-free survival was 4.0 months, and median overall survival was 8.1 months.

CONCLUSIONS:

In the modern context of mCRPC, mCTX may represent a valuable and inexpensive alternative to new agents, which have shown similar activity in heavily pretreated patients.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antineoplásicos Alquilantes / Ciclofosfamida / Neoplasias de la Próstata Resistentes a la Castración Tipo de estudio: Observational_studies / Prognostic_studies Límite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antineoplásicos Alquilantes / Ciclofosfamida / Neoplasias de la Próstata Resistentes a la Castración Tipo de estudio: Observational_studies / Prognostic_studies Límite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article