Expression of human T lymphocyte antigens by killer cells.
J Immunol
; 121(4): 1366-9, 1978 Oct.
Article
en En
| MEDLINE
| ID: mdl-308964
ABSTRACT
K cells, the effectors of antibody-dependent cell-mediated cytotoxicity, were found to express human T but not B lymphocyte antigens detected by rabbit anti-HTLA and anti-HBLA. Pretreatment of effector cells with anti-HTLA+C inhibited ADCC by specifically lysing K cells no inhibition of ADCC by anti-HTLA occurred when deltaC was substituted for C. By contrast, pretreatment of effector cells with anti-HBLA nonspecifically inhibited ADCC, probably for forming antigen-antibody complexes with HBLA+ cells in effector suspensions a) treatment with anti-HBLA deltaC was more inhibitory of ADCC than treatment with anti-HBLA+C, and b) the inhibitory effect of anti-HBLA on ADCC was either eliminated or markedly reduced if effector suspensions were first passed through a nylon fiber column, a procedure that removed most HBLA+ cells without affecting K cell activity. HTLA antigens expressed by K cells and NK cells are the same as HTLA antigens expressed by thymocytes since thymocytes completely absorb the anti-K cell and NK cell reactivity of anti-HTLA.
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Banco de datos:
MEDLINE
Asunto principal:
Células Asesinas Naturales
/
Linfocitos T
/
Antígenos
Límite:
Animals
/
Humans
Idioma:
En
Año:
1978
Tipo del documento:
Article