Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Diseaseã- Post Hoc Analysis of the FMD-J Study A.
Circ J
; 83(5): 1064-1071, 2019 04 25.
Article
en En
| MEDLINE
| ID: mdl-30918221
ABSTRACT
BACKGROUND:
Circulating triglyceride (TG) levels are a current focus as a residual risk for cardiovascular (CV) events. We evaluated the relationship between circulating TG levels and future CV events in patients with coronary artery disease (CAD) who were treated with conventional therapy. MethodsâandâResults:
We analyzed data for 652 patients who were enrolled in the FMD-J Study A. We investigated the associations between serum TG levels and first major CV events (death from CV cause, nonfatal acute coronary syndrome (ACS), nonfatal stroke, and CAD) for a 3-year follow-up period. Patients were divided into 4 groups based on serum TG level low-normal (<100 mg/dL), high-normal (100-149 mg/dL), borderline hypertriglyceridemia (150-199 mg/dL), and moderate hypertriglyceridemia (≥200 mg/dL). During a median follow-up period of 46.6 months, 14 patients died (9 from CV causes), 16 had nonfatal ACS, 6 had nonfatal stroke, and 54 had CAD. The Kaplan-Meier curves for first major CV event among the 4 groups were significantly different (P=0.04). After adjustment for various confounders, serum TG level ≥100 mg/dL were significantly associated with an increased risk of first major CV events compared with serum TG level <100 mg/dL.CONCLUSIONS:
Serum TG level may be a surrogate marker for predicting CV events in patients with CAD.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Triglicéridos
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Enfermedad de la Arteria Coronaria
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Accidente Cerebrovascular
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Síndrome Coronario Agudo
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2019
Tipo del documento:
Article