Nail squamous cell carcinoma: A hidden high-risk human papillomavirus reservoir for sexually transmitted infections.
J Am Acad Dermatol
; 81(6): 1358-1370, 2019 Dec.
Article
en En
| MEDLINE
| ID: mdl-30930083
ABSTRACT
Human papillomavirus (HPV) causes cervical cancer, anal cancer, vulvar cancer, vaginal cancer, penile cancer, and oropharyngeal cancer. Squamous cell carcinoma (SCC) in the genital region in particular is recognized to be caused by HPV infection, and intraepithelial lesions of the penis and vulva are termed penile intraepithelial neoplasia and vulvar intraepithelial neoplasia, respectively. Although SCC of the nail apparatus is recognized as being associated with high-risk HPVs, it is not well-known in general medicine, and its analysis has been insufficient. In this article, we reviewed 136 cases of HPV-associated nail SCC and SCC in situ and delineated their clinical characteristics. We found that half of the cases were high-risk HPV-associated. Almost all of the types were high-risk α-HPVs. This disease had a male dominance and left hand digit 3 and right hand digits 1-3 were typically affected. In this review, 24% of the cases of nail SCC had a history of other HPV-associated diseases, suggesting the possibility of genitodigital transmission. We propose that nail SCC is a hidden high-risk HPV-associated reservoir and should be recognized as a sexually transmitted infection.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Papillomaviridae
/
Neoplasias Cutáneas
/
Reservorios de Enfermedades
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Carcinoma de Células Escamosas
/
Enfermedades de Transmisión Sexual
/
Infecciones por Papillomavirus
/
Enfermedades de la Uña
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Female
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Humans
/
Male
Idioma:
En
Año:
2019
Tipo del documento:
Article