Ancient pathogen genomics as an emerging tool for infectious disease research.
Nat Rev Genet
; 20(6): 323-340, 2019 06.
Article
en En
| MEDLINE
| ID: mdl-30953039
ABSTRACT
Over the past decade, a genomics revolution, made possible through the development of high-throughput sequencing, has triggered considerable progress in the study of ancient DNA, enabling complete genomes of past organisms to be reconstructed. A newly established branch of this field, ancient pathogen genomics, affords an in-depth view of microbial evolution by providing a molecular fossil record for a number of human-associated pathogens. Recent accomplishments include the confident identification of causative agents from past pandemics, the discovery of microbial lineages that are now extinct, the extrapolation of past emergence events on a chronological scale and the characterization of long-term evolutionary history of microorganisms that remain relevant to public health today. In this Review, we discuss methodological advancements, persistent challenges and novel revelations gained through the study of ancient pathogen genomes.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Transmisibles
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Genoma
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Genómica
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Secuenciación de Nucleótidos de Alto Rendimiento
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ADN Antiguo
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article