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Proline-based hydroxamates targeting the zinc-dependent deacetylase LpxC: Synthesis, antibacterial properties, and docking studies.
Kalinin, Dmitrii V; Agoglitta, Oriana; Van de Vyver, Hélène; Melesina, Jelena; Wagner, Stefan; Riemann, Burkhard; Schäfers, Michael; Sippl, Wolfgang; Löffler, Bettina; Holl, Ralph.
  • Kalinin DV; Institute of Organic Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Germany; Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstr. 48, 4814
  • Agoglitta O; Institute of Organic Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Germany; NRW Graduate School of Chemistry, University of Münster, Germany.
  • Van de Vyver H; Cells-in-Motion Cluster of Excellence (EXC 1003 - CiM), University of Münster, Germany; Institute of Medical Microbiology, University Hospital Münster, Domagkstr. 10, 48149 Münster, Germany.
  • Melesina J; Institute of Pharmacy, Martin Luther University of Halle-Wittenberg, Wolfgang-Langenbeck Str. 4, 06120 Halle (Saale), Germany.
  • Wagner S; Department of Nuclear Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149 Münster, Germany.
  • Riemann B; Department of Nuclear Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149 Münster, Germany.
  • Schäfers M; Cells-in-Motion Cluster of Excellence (EXC 1003 - CiM), University of Münster, Germany; Department of Nuclear Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149 Münster, Germany; European Institute for Molecular Imaging, University of Münster, Waldeyerstraße 15, 48
  • Sippl W; Institute of Pharmacy, Martin Luther University of Halle-Wittenberg, Wolfgang-Langenbeck Str. 4, 06120 Halle (Saale), Germany.
  • Löffler B; Institute of Medical Microbiology, University Hospital Jena, Am Klinikum 1, 07747 Jena, Germany.
  • Holl R; Institute of Organic Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Germany. Electronic address: ralph.holl@chemie.uni-hamburg.de.
Bioorg Med Chem ; 27(10): 1997-2018, 2019 05 15.
Article en En | MEDLINE | ID: mdl-30954331
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Prolina / Amidohidrolasas / Ácidos Hidroxámicos / Antibacterianos Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Prolina / Amidohidrolasas / Ácidos Hidroxámicos / Antibacterianos Idioma: En Año: 2019 Tipo del documento: Article