Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1.
J Immunol
; 202(10): 2837-2842, 2019 05 15.
Article
en En
| MEDLINE
| ID: mdl-30962294
ABSTRACT
Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progenitors. Our data provide insight into the mechanisms controlling lymphocyte specification and may reveal a basis for the unique functions of Tal1 and Lyl1 in T acute lymphoblastic leukemia.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Diferenciación Celular
/
Células Progenitoras Mieloides
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Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico
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Células Progenitoras Linfoides
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Proteína 1 de la Leucemia Linfocítica T Aguda
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Proteínas de Neoplasias
Límite:
Animals
Idioma:
En
Año:
2019
Tipo del documento:
Article