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A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.
Zou, Yilong; Palte, Michael J; Deik, Amy A; Li, Haoxin; Eaton, John K; Wang, Wenyu; Tseng, Yuen-Yi; Deasy, Rebecca; Kost-Alimova, Maria; Dancík, Vlado; Leshchiner, Elizaveta S; Viswanathan, Vasanthi S; Signoretti, Sabina; Choueiri, Toni K; Boehm, Jesse S; Wagner, Bridget K; Doench, John G; Clish, Clary B; Clemons, Paul A; Schreiber, Stuart L.
  • Zou Y; The Broad Institute, Cambridge, MA, 02142, USA.
  • Palte MJ; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA.
  • Deik AA; The Broad Institute, Cambridge, MA, 02142, USA.
  • Li H; The Broad Institute, Cambridge, MA, 02142, USA.
  • Eaton JK; The Broad Institute, Cambridge, MA, 02142, USA.
  • Wang W; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA.
  • Tseng YY; The Broad Institute, Cambridge, MA, 02142, USA.
  • Deasy R; The Broad Institute, Cambridge, MA, 02142, USA.
  • Kost-Alimova M; The Broad Institute, Cambridge, MA, 02142, USA.
  • Dancík V; The Broad Institute, Cambridge, MA, 02142, USA.
  • Leshchiner ES; The Broad Institute, Cambridge, MA, 02142, USA.
  • Viswanathan VS; The Broad Institute, Cambridge, MA, 02142, USA.
  • Signoretti S; The Broad Institute, Cambridge, MA, 02142, USA.
  • Choueiri TK; The Broad Institute, Cambridge, MA, 02142, USA.
  • Boehm JS; Department of Oncologic Pathology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA.
  • Wagner BK; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA.
  • Doench JG; The Broad Institute, Cambridge, MA, 02142, USA.
  • Clish CB; The Broad Institute, Cambridge, MA, 02142, USA.
  • Clemons PA; The Broad Institute, Cambridge, MA, 02142, USA.
  • Schreiber SL; The Broad Institute, Cambridge, MA, 02142, USA.
Nat Commun ; 10(1): 1617, 2019 04 08.
Article en En | MEDLINE | ID: mdl-30962421
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico / Glutatión Peroxidasa / Neoplasias Renales / Proteínas de Neoplasias Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico / Glutatión Peroxidasa / Neoplasias Renales / Proteínas de Neoplasias Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article