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Calcium intake and colon cancer risk subtypes by tumor molecular characteristics.
Keum, NaNa; Liu, Li; Hamada, Tsuyoshi; Qian, Zhi Rong; Nowak, Jonathan A; Cao, Yin; da Silva, Annacarolina; Kosumi, Keisuke; Song, Mingyang; Nevo, Daniel; Wang, Molin; Chan, Andrew T; Meyerhardt, Jeffrey A; Fuchs, Charles S; Wu, Kana; Ogino, Shuji; Nishihara, Reiko; Zhang, Xuehong.
  • Keum N; Department of Nutrition, Harvard T.H. Chan School of Public Health, Building 2, 3rd Floor, 665 Huntington Avenue, Boston, MA, 02115, USA. nak212@mail.harvard.edu.
  • Liu L; Department of Food Science and Biotechnology, Dongguk University, Goyang, South Korea. nak212@mail.harvard.edu.
  • Hamada T; Department of Nutrition, Harvard T.H. Chan School of Public Health, Building 2, 3rd Floor, 665 Huntington Avenue, Boston, MA, 02115, USA.
  • Qian ZR; Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
  • Nowak JA; Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
  • Cao Y; Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
  • da Silva A; Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
  • Kosumi K; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Song M; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
  • Nevo D; Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
  • Wang M; Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
  • Chan AT; Department of Nutrition, Harvard T.H. Chan School of Public Health, Building 2, 3rd Floor, 665 Huntington Avenue, Boston, MA, 02115, USA.
  • Meyerhardt JA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Fuchs CS; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.
  • Wu K; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Ogino S; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Nishihara R; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Zhang X; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Cancer Causes Control ; 30(6): 637-649, 2019 Jun.
Article en En | MEDLINE | ID: mdl-30963391
ABSTRACT

BACKGROUND:

A preventive potential of high calcium intake against colorectal cancer has been indicated for distal colon cancer, which is inversely associated with high-level CpG island methylator phenotype (CIMP), high-level microsatellite instability (MSI), and BRAF and PIK3CA mutations. In addition, BRAF mutation is strongly inversely correlated with KRAS mutation. We hypothesized that the association between calcium intake and colon cancer risk might vary by these molecular features.

METHODS:

We prospectively followed 88,506 women from the Nurses' Health Study and 47,733 men from the Health Professionals Follow-up Study for up to 30 years. Duplication-method Cox proportional cause-specific hazards regression was used to estimate multivariable hazard ratios (HRs), and 95% confidence intervals (95% CIs) for the associations between calcium intake and the risk of colon cancer subtypes. By Bonferroni correction, the α-level was adjusted to 0.01.

RESULTS:

Based on 853 colon cancer cases, the inverse association between dietary calcium intake and colon cancer risk differed by CIMP status (pheterogeneity = 0.01). Per each 300 mg/day increase in intake, multivariable HRs were 0.84 (95% CI 0.76-0.94) for CIMP-negative/low and 1.12 (95% CI 0.93-1.34) for CIMP-high. Similar differential associations were suggested for MSI subtypes (pheterogeneity = 0.02), with the corresponding HR being 0.86 (95% CI 0.77-0.95) for non-MSI-high and 1.10 (95% CI 0.92-1.32) for MSI-high. No differential associations were observed by BRAF, KRAS, or PIK3CA mutations.

CONCLUSION:

The inverse association between dietary calcium intake and colon cancer risk may be specific to CIMP-negative/low and possibly non-MSI-high subtypes.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Calcio / Neoplasias del Colon / Islas de CpG / Proteínas Proto-Oncogénicas B-raf Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Calcio / Neoplasias del Colon / Islas de CpG / Proteínas Proto-Oncogénicas B-raf Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article