Insecticide resistance genes affect Culex quinquefasciatus vector competence for West Nile virus.
Proc Biol Sci
; 286(1894): 20182273, 2019 01 16.
Article
en En
| MEDLINE
| ID: mdl-30963855
ABSTRACT
Insecticide resistance has been reported to impact the interactions between mosquitoes and the pathogens they transmit. However, the effect on vector competence for arboviruses still remained to be investigated. We examined the influence of two insecticide resistance mechanisms on vector competence of the mosquito Culex quinquefasciatus for two arboviruses, Rift Valley Fever virus (RVFV) and West Nile virus (WNV). Three Cx. quinquefasciatus lines sharing a common genetic background were used two insecticide-resistant lines, one homozygous for amplification of the Ester2 locus (SA2), the other homozygous for the acetylcholinesterase ace-1 G119S mutation (SR) and the insecticide-susceptible reference line Slab. Statistical analyses revealed no significant effect of insecticide-resistant mechanisms on vector competence for RVFV. However, both insecticide resistance mechanisms significantly influenced the outcome of WNV infections by increasing the dissemination of WNV in the mosquito body, therefore leading to an increase in transmission efficiency by resistant mosquitoes. These results showed that insecticide resistance mechanisms enhanced vector competence for WNV and may have a significant impact on transmission dynamics of arboviruses. Our findings highlight the importance of understanding the impacts of insecticide resistance on the vectorial capacity parameters to assess the overall consequence on transmission.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fiebre del Nilo Occidental
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Virus del Nilo Occidental
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Resistencia a los Insecticidas
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Genes de Insecto
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Culex
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Mosquitos Vectores
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
2019
Tipo del documento:
Article