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Development of Poly(ɛ-caprolactone) Scaffold Loaded with Simvastatin and Beta-Cyclodextrin Modified Hydroxyapatite Inclusion Complex for Bone Tissue Engineering.
Lee, Jung Bok; Kim, Ji Eun; Bae, Min Soo; Park, Su A; Balikov, Daniel A; Sung, Hak-Joon; Jeon, Hoon Bong; Park, Hun Kuk; Um, Soong Ho; Lee, Kook Sun; Kwon, Il Keun.
  • Lee JB; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212, USA. jung.bok.lee@vanderbilt.edu.
  • Kim JE; Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37235, USA. jung.bok.lee@vanderbilt.edu.
  • Bae MS; Department of Maxillofacial Biomedical Engineering, Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Korea. sausage14@khu.ac.kr.
  • Park SA; Department of Maxillofacial Biomedical Engineering, Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Korea. bmsbms20@gmail.com.
  • Balikov DA; Department of Nature-Inspired Nanoconvergence Systems, Korea Institute of Machinery and Materials, 156 Gajeongbuk-ro, Yuseong-gu, Daejeon 304-343, Korea. psa@kimm.re.kr.
  • Sung HJ; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212, USA. daniel.a.balikov@vanderbilt.edu.
  • Jeon HB; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212, USA. hak-joon.sung@vanderbilt.edu.
  • Park HK; Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN 37235, USA. hak-joon.sung@vanderbilt.edu.
  • Um SH; Severance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul 120-752, Korea. hak-joon.sung@vanderbilt.edu.
  • Lee KS; Department of Biomedical Engineering, College of Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Korea. inwoodkr@gmail.com.
  • Kwon IK; Department of Biomedical Engineering, College of Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Korea. sigmoidus@khu.ac.kr.
Polymers (Basel) ; 8(2)2016 Feb 09.
Article en En | MEDLINE | ID: mdl-30979140
ABSTRACT
In this study, we developed poly(ɛ-caprolactone) (PCL) 3D scaffolds using a solid free form fabrication (SFF) technique. ß-cyclodextrin (ßCD) was grafted to hydroxyapatite (HAp) and this ßCD grafted HAp was coated onto the PCL scaffold surface, followed by drug loading through an inclusion complex interaction between the ßCD and adamantane (AD) or between ßCD and simvastatin (SIM). The scaffold structure was characterized by scanning electron microscopy (SEM). The release profile of simvastatin in the ß-CD grafted HAp was also evaluated. Osteogenic differentiation of adipose-derived stromal cells (ADSCs) was examined using an alkaline phosphatase activity (ALP) assay. The results suggest that drug loaded PCL-HAp 3-D scaffolds enhances osteogenic differentiation of ADSCs.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2016 Tipo del documento: Article