Effects of caffeic acid phenethyl ester (CAPE) on angiogenesis, apoptosis and oxidative stress in various cancer cell lines.
Biotech Histochem
; 94(7): 491-497, 2019 Oct.
Article
en En
| MEDLINE
| ID: mdl-30991851
ABSTRACT
Cancer is a common cause of death worldwide. Approximately 80% of cancer patients use complementary or alternative medicines for treatment. Caffeic acid phenethyl ester (CAPE), the main active component of propolis, exhibits cytotoxic, antiproliferative and anti-cancer effects. Despite its anticancer effects CAPE exhibits no known harmful effects toward normal cells. We investigated the effects of CAPE on angiogenesis, apoptosis and oxidative stress using MDA MB-231, N2a and COLO 320 cell lines and CAPE treatments at 24 and 48 h. A two dimensional cell culture system was used and the findings were evaluated by an indirect immunohistochemical method and H-scores were calculated. CAPE was effective for all three cancer cell lines. After 24 and 48 h, we found a significant decrease in live cells and increased stress in the cells based on e-NOS and i-NOS levels.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Alcohol Feniletílico
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Ácidos Cafeicos
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Apoptosis
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Estrés Oxidativo
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Inductores de la Angiogénesis
Límite:
Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article