Total Synthesis of Aspidosperma and Strychnos Alkaloids through Indole Dearomatization.

Saya, Jordy M; Ruijter, Eelco; Orru, Romano V A

Saya, Jordy M; Ruijter, Eelco; Orru, Romano V A.

Saya JM; Department of Chemistry & Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines & Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.
Ruijter E; Department of Chemistry & Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines & Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.
Orru RVA; Department of Chemistry & Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines & Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.

Chemistry ; 25(38): 8916-8935, 2019 Jul 05.

Article en En | MEDLINE | ID: mdl-30994212

RESUMEN

Monoterpenoid indole alkaloids are the major class of tryptamine-derived alkaloids found in nature. Together with their structural complexity, this has attracted great interest from synthetic organic chemists. In this Review, the syntheses of Aspidosperma and Strychnos alkaloids through dearomatization of indoles are discussed.

Asunto(s)

Alcaloides/síntesis química; Aspidosperma/química; Técnicas de Química Sintética/métodos; Strychnos/química; Alcaloides/química; Reacción de Cicloadición/métodos; Alcaloides de Triptamina Secologanina/síntesis química; Alcaloides de Triptamina Secologanina/química

Palabras clave

alkaloids; biomimetic synthesis; dearomatization; indoles; natural product synthesis

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aspidosperma / Strychnos / Alcaloides / Técnicas de Química Sintética Idioma: En Año: 2019 Tipo del documento: Article

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