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Non-genotoxic MDM2 inhibition selectively induces a pro-apoptotic p53 gene signature in chronic lymphocytic leukemia cells.
Ciardullo, Carmela; Aptullahoglu, Erhan; Woodhouse, Laura; Lin, Wei-Yu; Wallis, Jonathan P; Marr, Helen; Marshall, Scott; Bown, Nick; Willmore, Elaine; Lunec, John.
  • Ciardullo C; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Aptullahoglu E; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Woodhouse L; Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne.
  • Lin WY; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Wallis JP; Department of Haematology, Freeman Hospital, The Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne.
  • Marr H; Department of Haematology, Freeman Hospital, The Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne.
  • Marshall S; Department of Haematology, City Hospitals Sunderland NHS Trust, Sunderland.
  • Bown N; Northern Genetics Service, Institute of Genetic Medicine, Newcastle upon Tyne, UK.
  • Willmore E; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Lunec J; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne john.lunec@ncl.ac.uk.
Haematologica ; 104(12): 2429-2442, 2019 12.
Article en En | MEDLINE | ID: mdl-31004033
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirrolidinas / Leucemia Mielógena Crónica BCR-ABL Positiva / Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / Proteína p53 Supresora de Tumor / Apoptosis / Proteínas Proto-Oncogénicas c-mdm2 / Para-Aminobenzoatos Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
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XML
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirrolidinas / Leucemia Mielógena Crónica BCR-ABL Positiva / Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / Proteína p53 Supresora de Tumor / Apoptosis / Proteínas Proto-Oncogénicas c-mdm2 / Para-Aminobenzoatos Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article