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The Impact of Caloric Restriction on the Epigenetic Signatures of Aging.
Gensous, Noémie; Franceschi, Claudio; Santoro, Aurelia; Milazzo, Maddalena; Garagnani, Paolo; Bacalini, Maria Giulia.
  • Gensous N; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40126 Bologna, Italy. noemie_gensous@hotmail.com.
  • Franceschi C; IRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy. claudio.franceschi@unibo.it.
  • Santoro A; Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia. claudio.franceschi@unibo.it.
  • Milazzo M; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40126 Bologna, Italy. aurelia.santoro@unibo.it.
  • Garagnani P; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40126 Bologna, Italy. maddimilazzo@hotmail.it.
  • Bacalini MG; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40126 Bologna, Italy. paolo.garagnani2@unibo.it.
Int J Mol Sci ; 20(8)2019 Apr 24.
Article en En | MEDLINE | ID: mdl-31022953
ABSTRACT
Aging is characterized by an extensive remodeling of epigenetic patterns, which has been implicated in the physiopathology of age-related diseases. Nutrition plays a significant role in modulating the epigenome, and a growing amount of data indicate that dietary changes can modify the epigenetic marks associated with aging. In this review, we will assess the current advances in the relationship between caloric restriction, a proven anti-aging intervention, and epigenetic signatures of aging. We will specifically discuss the impact of caloric restriction on epigenetic regulation and how some of the favorable effects of caloric restriction on lifespan and healthspan could be mediated by epigenetic modifications.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Envejecimiento / Restricción Calórica / Epigénesis Genética Límite: Animals / Humans Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Envejecimiento / Restricción Calórica / Epigénesis Genética Límite: Animals / Humans Idioma: En Año: 2019 Tipo del documento: Article