Lymphatic Endothelial Cells Are Essential Components of the Subcapsular Sinus Macrophage Niche.
Immunity
; 50(6): 1453-1466.e4, 2019 06 18.
Article
en En
| MEDLINE
| ID: mdl-31053503
ABSTRACT
In lymph nodes, subcapsular sinus macrophages (SSMs) form an immunological barrier that monitors lymph drained from peripheral tissues. Upon infection, SSMs activate B and natural killer T (NKT) cells while secreting inflammatory mediators. Here, we investigated the mechanisms regulating development and homeostasis of SSMs. Embryonic SSMs originated from yolk sac hematopoiesis and were replaced by a postnatal wave of bone marrow (BM)-derived monocytes that proliferated to establish the adult SSM network. The SSM network self-maintained by proliferation with minimal BM contribution. Upon pathogen-induced transient deletion, BM-derived cells contributed to restoring the SSM network. Lymphatic endothelial cells (LECs) were the main source of CSF-1 within the lymph node and conditional deletion of Csf1 in adult LECs decreased the network of SSMs and medullary sinus macrophages (MSMs). Thus, SSMs have a dual hematopoietic origin, and LECs are essential to the niche supporting these macrophages.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Endoteliales
/
Macrófagos
Límite:
Animals
Idioma:
En
Año:
2019
Tipo del documento:
Article