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Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition.
Esler, William P; Tesz, Gregory J; Hellerstein, Marc K; Beysen, Carine; Sivamani, Raja; Turner, Scott M; Watkins, Steven M; Amor, Paul A; Carvajal-Gonzalez, Santos; Geoly, Frank J; Biddle, Kathleen E; Purkal, Julie J; Fitch, Mark; Buckeridge, Clare; Silvia, Annette M; Griffith, David A; Gorgoglione, Matthew; Hassoun, Lauren; Bosanac, Suzana S; Vera, Nicholas B; Rolph, Timothy P; Pfefferkorn, Jeffrey A; Sonnenberg, Gabriele E.
  • Esler WP; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Global Research and Development, Cambridge, MA 02139, USA. william.esler@pfizer.com.
  • Tesz GJ; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Global Research and Development, Cambridge, MA 02139, USA.
  • Hellerstein MK; KineMed Inc., Emeryville, CA 94608, USA.
  • Beysen C; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
  • Sivamani R; KineMed Inc., Emeryville, CA 94608, USA.
  • Turner SM; Department of Dermatology, School of Medicine, University of California, Davis, Davis, CA 95816, USA.
  • Watkins SM; KineMed Inc., Emeryville, CA 94608, USA.
  • Amor PA; Verso Biosciences, Davis, CA 95618, USA.
  • Carvajal-Gonzalez S; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Global Research and Development, Cambridge, MA 02139, USA.
  • Geoly FJ; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Global Research and Development, Cambridge, MA 02139, USA.
  • Biddle KE; Drug Safety Research and Development, Pfizer Global Research and Development, Groton, CT 06340, USA.
  • Purkal JJ; Drug Safety Research and Development, Pfizer Global Research and Development, Groton, CT 06340, USA.
  • Fitch M; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Global Research and Development, Cambridge, MA 02139, USA.
  • Buckeridge C; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
  • Silvia AM; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Global Research and Development, Cambridge, MA 02139, USA.
  • Griffith DA; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Global Research and Development, Cambridge, MA 02139, USA.
  • Gorgoglione M; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Global Research and Development, Cambridge, MA 02139, USA.
  • Hassoun L; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Global Research and Development, Cambridge, MA 02139, USA.
  • Bosanac SS; Department of Dermatology, School of Medicine, University of California, Davis, Davis, CA 95816, USA.
  • Vera NB; Department of Dermatology, School of Medicine, University of California, Davis, Davis, CA 95816, USA.
  • Rolph TP; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Global Research and Development, Cambridge, MA 02139, USA.
  • Pfefferkorn JA; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Global Research and Development, Cambridge, MA 02139, USA.
  • Sonnenberg GE; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Global Research and Development, Cambridge, MA 02139, USA.
Sci Transl Med ; 11(492)2019 05 15.
Article en En | MEDLINE | ID: mdl-31092695
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Acetil-CoA Carboxilasa / Sebo / Acné Vulgar / Inhibidores Enzimáticos / Lipogénesis Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Acetil-CoA Carboxilasa / Sebo / Acné Vulgar / Inhibidores Enzimáticos / Lipogénesis Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article