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A Safe and Efficient Strategy for the Rapid Elimination of Blood Lead In Vivo Based on a Capture-Fix-Separate Mechanism.
Wan, Mi Mi; Xu, Ting Ting; Chi, Bo; Wang, Meng; Huang, Yangyang; Wang, Qi; Li, Ting; Yan, Wen Qiang; Chen, Huan; Xu, Ping; Mao, Chun; Zhao, Bo; Shen, Jian; Xu, Hong; Shi, Dong Quan.
  • Wan MM; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
  • Xu TT; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
  • Chi B; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Jiangsu National Synergetic Innovation Center for Advanced, Materials, Nanjing Tech University, Nanjing, 211816, China.
  • Wang M; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
  • Huang Y; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
  • Wang Q; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
  • Li T; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
  • Yan WQ; Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
  • Chen H; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
  • Xu P; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
  • Mao C; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
  • Zhao B; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
  • Shen J; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
  • Xu H; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Jiangsu National Synergetic Innovation Center for Advanced, Materials, Nanjing Tech University, Nanjing, 211816, China.
  • Shi DQ; Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
Angew Chem Int Ed Engl ; 58(31): 10582-10586, 2019 07 29.
Article en En | MEDLINE | ID: mdl-31111993
Lead poisoning is an important problem because of its serious effects on human health. Yet a solution is not available due to an incomplete understanding of the state of lead ions in blood. Since most blood lead binds to hemoglobin (Hb) in red blood cells, identifying and capturing lead-contaminated Hb in RBCs is important. Herein, a magnetic blood lead remover with hyperbranched poly(amidoamine)s (HPAM) as template/co-adsorbent and core-shell mesoporous structure was synthesized. Lead-containing Hb was selectively captured and then fixed by mesoporous channels. The magnetic separation technology was used to separate the magnetic remover from blood. A related blood lead clean-up apparatus was used to remove lead from the blood of a pig in vivo. Results of physical/chemical characterizations, biocompatibility experiments, animal tests, and theoretical simulation verify the safety and efficiency of this removal strategy and the high efficiency of the blood lead clean-up apparatus.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Plomo Límite: Animals Idioma: En Año: 2019 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Plomo Límite: Animals Idioma: En Año: 2019 Tipo del documento: Article