Manganese in PET imaging: Opportunities and challenges.
J Labelled Comp Radiopharm
; 62(8): 541-551, 2019 06 30.
Article
en En
| MEDLINE
| ID: mdl-31115089
ABSTRACT
Several radionuclides of the transition metal manganese are known and accessible. Three of them, 51 Mn, 52m Mn, and 52g Mn, are positron emitters that are potentially interesting for positron emission tomography (PET) applications and, thus, have caught the interest of the radiochemical/radiopharmaceutical and nuclear medicine communities. This mini-review provides an overview of the production routes and physical properties of these radionuclides. For medical imaging, the focus is on the longer-living 52g Mn and its application for the radiolabelling of molecules and other entities exhibiting long biological half-lives, the imaging of manganese-dependent biological processes, and the development of bimodal PET/magnetic resonance imaging (MRI) probes in combination with paramagnetic nat Mn as a contrast agent.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tomografía de Emisión de Positrones
/
Manganeso
Límite:
Animals
/
Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article