The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in Arabidopsis.
Proc Natl Acad Sci U S A
; 116(25): 12534-12539, 2019 06 18.
Article
en En
| MEDLINE
| ID: mdl-31164422
ABSTRACT
Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in ArabidopsisArabidopsis plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions. Interestingly, this reduction of type I CO did not affect CO assurance, a mechanism by which each chromosome receives at least one CO, resulting in all chromosomes exhibiting similar genetic lengths in weak loss-of-function cdka;1 mutants. Conversely, an increase of CDKA;1 activity resulted in elevated recombination frequencies. Thus, modulation of CDKA;1 kinase activity affects the number and placement of COs along the chromosome axis in a dose-dependent manner.
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Banco de datos:
MEDLINE
Asunto principal:
Recombinación Genética
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Arabidopsis
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Quinasas Ciclina-Dependientes
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Proteínas de Arabidopsis
Idioma:
En
Año:
2019
Tipo del documento:
Article