CHML promotes liver cancer metastasis by facilitating Rab14 recycle.
Nat Commun
; 10(1): 2510, 2019 06 07.
Article
en En
| MEDLINE
| ID: mdl-31175290
ABSTRACT
Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurrence and more satellite nodules in HCC patients. CHML promotes migration, invasion and metastasis of HCC cells, in a Rab14-dependent manner. Mechanism study reveals that CHML facilitates constant recycling of Rab14 by escorting Rab14 to the membrane. Furthermore, we identify several metastasis regulators as cargoes carried by Rab14-positive vesicles, including Mucin13 and CD44, which may contribute to metastasis-promoting effects of CHML. Altogether, our data establish CHML as a potential promoter of HCC metastasis, and the CHML-Rab14 axis may be a promising therapeutic target for HCC.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Carcinoma Hepatocelular
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Proteínas de Unión al GTP rab
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Proteínas Adaptadoras Transductoras de Señales
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Neoplasias Hepáticas
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Neoplasias Primarias Múltiples
Límite:
Animals
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Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article