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Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.
Claus, Christina; Ferrara, Claudia; Xu, Wei; Sam, Johannes; Lang, Sabine; Uhlenbrock, Franziska; Albrecht, Rosmarie; Herter, Sylvia; Schlenker, Ramona; Hüsser, Tamara; Diggelmann, Sarah; Challier, John; Mössner, Ekkehard; Hosse, Ralf J; Hofer, Thomas; Brünker, Peter; Joseph, Catherine; Benz, Jörg; Ringler, Philippe; Stahlberg, Henning; Lauer, Matthias; Perro, Mario; Chen, Stanford; Küttel, Christine; Bhavani Mohan, Preethi L; Nicolini, Valeria; Birk, Martina Carola; Ongaro, Amandine; Prince, Christophe; Gianotti, Reto; Dugan, Gregory; Whitlow, Christopher T; Solingapuram Sai, Kiran Kumar; Caudell, David L; Burgos-Rodriguez, Armando G; Cline, J Mark; Hettich, Michael; Ceppi, Maurizio; Giusti, Anna Maria; Crameri, Flavio; Driessen, Wouter; Morcos, Peter N; Freimoser-Grundschober, Anne; Levitsky, Victor; Amann, Maria; Grau-Richards, Sandra; von Hirschheydt, Thomas; Tournaviti, Stella; Mølhøj, Michael; Fauti, Tanja.
  • Claus C; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Ferrara C; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Xu W; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Sam J; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Lang S; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Uhlenbrock F; University of Basel, Department of Biomedicine, Hebelstrasse 20, 4031 Basel, Switzerland.
  • Albrecht R; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Herter S; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Schlenker R; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Hüsser T; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Diggelmann S; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Challier J; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Mössner E; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Hosse RJ; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Hofer T; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Brünker P; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Joseph C; Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Benz J; Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Ringler P; University of Basel, Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, Klingelbergstrasse 70, 4056 Basel, Switzerland.
  • Stahlberg H; University of Basel, Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, Klingelbergstrasse 70, 4056 Basel, Switzerland.
  • Lauer M; Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Perro M; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Chen S; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Küttel C; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Bhavani Mohan PL; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Nicolini V; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Birk MC; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Ongaro A; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Prince C; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Gianotti R; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Dugan G; Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
  • Whitlow CT; Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
  • Solingapuram Sai KK; Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
  • Caudell DL; Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
  • Burgos-Rodriguez AG; Caribbean Primate Research Center, PO Box 1053, Sabana Seca, Puerto Rico 00952, USA.
  • Cline JM; Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
  • Hettich M; Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Ceppi M; Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Giusti AM; Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Crameri F; Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Driessen W; Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Morcos PN; Roche Innovation Center New York, pRED, 430 E 29th St, New York, NY 10016, USA.
  • Freimoser-Grundschober A; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Levitsky V; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Amann M; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • Grau-Richards S; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  • von Hirschheydt T; Roche Innovation Center Munich, pRED, Nonnenwald 2, 82377 Penzberg, Germany.
  • Tournaviti S; Roche Innovation Center Munich, pRED, Nonnenwald 2, 82377 Penzberg, Germany.
  • Mølhøj M; Roche Innovation Center Munich, pRED, Nonnenwald 2, 82377 Penzberg, Germany.
  • Fauti T; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Sci Transl Med ; 11(496)2019 06 12.
Article en En | MEDLINE | ID: mdl-31189721
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Anticuerpos Biespecíficos / Linfocitos T CD8-positivos Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Anticuerpos Biespecíficos / Linfocitos T CD8-positivos Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article