Determination of five nucleosides by LC-MS/MS and the application of the method to quantify N<sup>6</sup> -methyladenosine level in liver messenger ribonucleic acid of an acetaminophen-induced hepatotoxicity mouse model.

Liu, Ruijuan; Zhao, Fang; Wei, Jingyao; Yu, Pei; Zhang, Ji; Wang, Yueqin; Li, Zeyun; Zhang, Jiali; Zhang, Xiaojian; Tian, Xin

Determination of five nucleosides by LC-MS/MS and the application of the method to quantify N⁶ -methyladenosine level in liver messenger ribonucleic acid of an acetaminophen-induced hepatotoxicity mouse model.

Liu, Ruijuan; Zhao, Fang; Wei, Jingyao; Yu, Pei; Zhang, Ji; Wang, Yueqin; Li, Zeyun; Zhang, Jiali; Zhang, Xiaojian; Tian, Xin.

Liu R; Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China.
Zhao F; Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou, P. R. China.
Wei J; Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China.
Yu P; Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou, P. R. China.
Zhang J; Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China.
Wang Y; Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou, P. R. China.
Li Z; Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China.
Zhang J; Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou, P. R. China.
Zhang X; Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China.
Tian X; Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou, P. R. China.

J Sep Sci ; 42(16): 2668-2678, 2019 Aug.

Article en En | MEDLINE | ID: mdl-31197931

Asunto(s)

Adenosina/análisis; Enfermedad Hepática Inducida por Sustancias y Drogas/genética; Citidina/análisis; Guanosina/análisis; Hígado/metabolismo; ARN Mensajero/química; Uridina/análisis; Acetaminofén; Adenosina/análogos & derivados; Animales; Cromatografía Líquida de Alta Presión; Modelos Animales de Enfermedad; Masculino; Ratones; Espectrometría de Masas en Tándem

Palabras clave

acetaminophen; hepatotoxicity; liquid chromatography; nucleosides; tandem mass spectrometry

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Uridina / ARN Mensajero / Adenosina / Citidina / Enfermedad Hepática Inducida por Sustancias y Drogas / Guanosina / Hígado Límite: Animals Idioma: En Año: 2019 Tipo del documento: Article

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