[Clinical Features and Prognostic Factors of 18 Children with Anaplastic Large Cell Lymphoma].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
; 27(3): 809-915, 2019 Jun.
Article
en Zh
| MEDLINE
| ID: mdl-31204936
ABSTRACT
OBJECTIVE:
To analyze the clinical features and to explore the therapeutic efficacy and prognostic factors of children with anaplastic large cell lymphoma (ALCL).METHODS:
The clinical data of 18 children with ALCL admitted in Department of Pediatric Hematology, Union Hospital of Fujian Medical University from April 2011 to November 2017 was collected and analyzed.RESULTS:
The male to female ratio was 2â¶1, the median age of onset was 6 (0.9-11.3) years old, and the B symptom was positive in 13 cases. The most common initial symptom was lymphadenopathy (in 17 cases). All patients were manifested with multiple organ involvements. 4 cases were classified as clinical stage â ¡, 11 cases as stage â ¢, and 3 cases as stage â £. Laboratory tests revealed 9 cases with leukocytosis and 8 cases with CRPï¼20 mg/L. The pathological results showed all ALK-positive anaplastic large cell lymphoma with Ki-67 rate between 40%-90%. The median follow-up time was 41 months. 2 patients died before treatment, 1 patient was lost to follow-up. 15 patients accepted chemotherapy protocol of CCCG-BNHL-2011. 2 patients relapsed early, the 3 year event-free survival rate was (76.7±10.2)%. Kaplan-Meier survival analysis showed leukocytosis, increased CRP level, bone involvement and clinical stage were factors affecting prognosis.CONCLUSION:
ALCL is a relatively rare subtype of childhood non-Hodgkin's lymphoma with high invasiveness. Leukocytosis, increased CRP level, bone involvement and clinical stage are poor factors affecting the prognosis of patients.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfoma Anaplásico de Células Grandes
Tipo de estudio:
Guideline
/
Prognostic_studies
Límite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
Zh
Año:
2019
Tipo del documento:
Article