XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence.

Hou, Shuai; Qu, Dajun; Li, Yue; Zhu, Baohui; Liang, Dapeng; Wei, Xinyue; Tang, Wei; Zhang, Qian; Hao, Jiaojiao; Guo, Wei; Wang, Weijie; Zhao, Siqi; Wang, Qi; Azam, Sikandar; Khan, Misbah; Zhao, Haidong; Zhang, Liye; Lei, Haixin

Hou, Shuai; Qu, Dajun; Li, Yue; Zhu, Baohui; Liang, Dapeng; Wei, Xinyue; Tang, Wei; Zhang, Qian; Hao, Jiaojiao; Guo, Wei; Wang, Weijie; Zhao, Siqi; Wang, Qi; Azam, Sikandar; Khan, Misbah; Zhao, Haidong; Zhang, Liye; Lei, Haixin.

Hou S; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
Qu D; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
Li Y; Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, Second Affiliated Hospital, Dalian Medical University, Dalian, China.
Zhu B; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
Liang D; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
Wei X; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
Tang W; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Zhang Q; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
Hao J; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
Guo W; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
Wang W; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
Zhao S; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
Wang Q; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
Azam S; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
Khan M; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
Zhao H; Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, Second Affiliated Hospital, Dalian Medical University, Dalian, China.
Zhang L; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Lei H; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.

Nucleic Acids Res ; 47(15): 8239-8254, 2019 09 05.

Article en En | MEDLINE | ID: mdl-31216022

Asunto(s)

Senescencia Celular/genética; ARN Polimerasas Dirigidas por ADN/genética; Intrones/genética; Factores de Transcripción/genética; Transcripción Genética; Línea Celular; Línea Celular Tumoral; ARN Polimerasas Dirigidas por ADN/metabolismo; Células HEK293; Células HeLa; Humanos; Interferencia de ARN; Empalme del ARN; Factores de Empalme de ARN; ARN Mensajero/genética; ARN Mensajero/metabolismo; Factores de Transcripción/metabolismo; Proteína p53 Supresora de Tumor/genética; Proteína p53 Supresora de Tumor/metabolismo

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Transcripción Genética / ARN Polimerasas Dirigidas por ADN / Intrones / Senescencia Celular Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article

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