Late-Onset Circulatory Collapse and Risk of Cerebral Palsy in Extremely Preterm Infants.
J Pediatr
; 212: 117-123.e4, 2019 09.
Article
en En
| MEDLINE
| ID: mdl-31229321
ABSTRACT
OBJECTIVE:
To investigate whether the development of postnatal, late-onset refractory hypotension, referred to as late-onset circulatory collapse, was associated with an increased risk of developing cerebral palsy (CP) at 3 years of age in extremely preterm infants.METHODS:
In this historical cohort study, infants who were born at 22-27 weeks of gestation from 2008 to 2012 in the Neonatal Research Network of Japan were eligible. The study sample consisted of 3474 infants (45.6% of 7613 potentially eligible infants) who were evaluated at 36-42 months of age. Late-onset circulatory collapse was defined as a clinical diagnosis of late-onset circulatory collapse requiring treatment with corticosteroids. We compared the neurodevelopmental outcomes between infants with and without late-onset circulatory collapse.RESULTS:
Late-onset circulatory collapse was diagnosed in 666 of the infants studied. Infants with late-onset circulatory collapse had a higher incidence of CP than those without late-onset circulatory collapse (18.0% vs 9.8%; P < .01). In multivariable logistic analysis, late-onset circulatory collapse was independently associated with CP (aOR, 1.52; 95% CI, 1.13-2.04) and developmental quotient score of <50 (OR, 1.83; 95% CI, 1.23-2.72).CONCLUSIONS:
Late-onset circulatory collapse may be a relatively common event occurring in extremely preterm infants and an independent risk factor for CP at 3 years of age.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Choque
/
Parálisis Cerebral
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Enfermedades del Prematuro
Tipo de estudio:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Límite:
Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
País como asunto:
Asia
Idioma:
En
Año:
2019
Tipo del documento:
Article