Issues in assessing the health risks of n-butanol.
J Appl Toxicol
; 40(1): 72-86, 2020 01.
Article
en En
| MEDLINE
| ID: mdl-31231852
ABSTRACT
A literature review and health effects evaluation were conducted for n-butanol, a chemical that occurs naturally in some foods, which is an intermediate in the production of butyl esters and can be used as a gasoline additive or blend. Studies evaluating n-butyl acetate were included in the review as n-butyl acetate is rapidly converted to n-butanol following multiple routes of exposure. The primary n-butanol health effects identified were developmental and nervous system endpoints. In conducting the literature review and evaluating study findings, the following observations were made (1) developmental findings were consistently identified; (2) neurodevelopmental findings were inconsistent; (3) evidence for nervous system effects was weak; (4) comparing internal doses from oral and inhalation exposures using physiologically based pharmacokinetic models introduces uncertainties; and (5) a lack of mechanistic information for n-butanol resulted in the reliance on mechanistic data for ethanol, which may or may not be applicable to n-butanol. This paper presents findings from a literature review on the health effects of n-butanol and proposes research to help reduce uncertainty that exists due to database limitations.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pruebas de Toxicidad
/
1-Butanol
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Síndromes de Neurotoxicidad
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Contaminantes Ambientales
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Acetatos
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Sistema Nervioso
Tipo de estudio:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Animals
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Female
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Humans
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Pregnancy
Idioma:
En
Año:
2020
Tipo del documento:
Article