Early life exposure to coal mine fire smoke emissions and altered lung function in young children.
Respirology
; 25(2): 198-205, 2020 02.
Article
en En
| MEDLINE
| ID: mdl-31231911
ABSTRACT
BACKGROUND AND OBJECTIVE:
Long-term respiratory risks following exposure to relatively short periods of poor air quality early in life are unknown. We aimed to evaluate the association between exposure to a 6-week episode of air pollution from a coal mine fire in children aged <2 years, and their lung function 3 years after the fire.METHODS:
We conducted a prospective cohort study. Individual exposure to 24-h average and peak concentrations of particulate matter with an aerodynamic diameter <2.5 µm in diameter (PM2.5 ) during the fire were estimated using dispersion and chemical transport modelling. Lung function was measured using the forced oscillation technique (FOT), generating standardized Z-scores for resistance and reactance at a frequency of 5 Hz (Rrs5 and Xrs5 ), and area under the reactance curve (AX). We used linear regression models to assess the associations between PM2.5 exposure and lung function, adjusted for potential confounders.RESULTS:
Of the 203 infants originally recruited, 84 aged 4.3 ± 0.5 years completed FOT testing. Median (interquartile range, IQR) for average and peak PM2.5 were 7.9 (6.8-16.8) and 103.4 (60.6-150.7) µg/m3 , respectively. The mean ± SD Z-scores for Rrs5 , Xrs5 and AX were 0.56 ± 0.80, -0.76 ± 0.88 and 0.72 ± 0.92, respectively. After adjustment for potential confounders including maternal smoking during pregnancy, a 10 µg/m3 increase in average PM2.5 was significantly associated with worsening AX (ß-coefficient 0.260; 95% CI 0.019, 0.502), while the association between a 100-µg/m3 increase in peak PM2.5 and AX was borderline (0.166; 95% CI -0.002, 0.334).CONCLUSION:
Infant exposure to coal mine fire emissions could be associated with long-term impairment of lung reactance.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Humo
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Contaminantes Atmosféricos
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Exposición a Riesgos Ambientales
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Material Particulado
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Pulmón
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Child, preschool
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Female
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Humans
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Infant
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Male
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Pregnancy
Idioma:
En
Año:
2020
Tipo del documento:
Article